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Where the cells stick, they reduce oxygen flow to tissues and thisresults in pain. In the most severe cases suchrecurrent and chronic lack of oxygen leads to distorted bones in the fingers and the toes, chronic tiredness through anaemia and damage to structures throughout the body especially the kidneys and the brain.People may have the sickle cell trait; these get no symptoms at all unless they have an especially severe infection or are exposed to low oxygen conditions e.g. during anaesthesia.Those whohave out and out sickle cell disease are more likely to get chronic problems.The condition is detectable by a simple blood test.

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